KaryoLogic Inc was formed in 2008 and opened for business in 2009. Founder Elizabeth Gonzalez envisioned a mission of providing high quality chromosome karyotyping services to researchers across the globe. Initially starting out with human and mouse karyotyping services, over time, fluorescence in situ hybridization services, and karyotyping of many other species, have been added. More recently, digital PCR assay of human stem cells has become another offering. We strive to contribute our skills in ways that best serve our clients’ needs. Thank you for considering our team for your research project.
Elizabeth Gonzalez is a graduate of Cornell University, BS 1983, and Rutgers University, MS 1988. Her background includes experience in the clinical cytogenetics hospital setting (6 years), the university research setting (10 years), and the genetic toxicology industry (3 years). She began learning and working with the human karyotype in 1982, then mastered the more challenging mouse karyotype in 1992. With this background, in 2008 Ms. Gonzalez launched Karyologic Inc to offer her karyotyping skills to the global scientific community. She enjoys training younger cytogenetic technologists, thus proudly passing on the knowledge she has gained through the years.
Key scientific publications co-authored by Elizabeth Gonzalez (formerly known as Elizabeth Livanos)
Fulcher ML, Gabriel SE, Olsen JC, Tatreau JR, Gentzch M, Livanos E, Saavedra MT, Salmon P, and Randell SH. Novel human bronchial epithelial cell lines for cystic fibrosis research. Am J Physiol Lung Cell Mol Physiol. 296 (1): L82-91, 2009.
Simpson DA, Livanos E, Heffernan TP, and Kaufmann WK. Telomerase expression is sufficient for chromosomal integrity in cells lacking p53 dependent G1 checkpoint function. J. Carcinog. 4:18-34, 2005.
Slebos RJ, Livanos E, Yim HW, Randell SH, Parsons AM, Detterbeck FC, Rivera MP, and Taylor JA. Chromosomal abnormalities in bronchial epithelium from smokers, non-smokers, and lung cancer patients. Cancer Genet Cytogenet. 159 (2): 137-142, 2005.
Coleman WB, McCullough KD, Esch GL, Civalier CJ, Livanos E, Weissman BE, Grisham JW, and Smith GJ. Suppression of tumorigenic phenotype of a rat liver epithelial tumor cell line by the p11.2-p12 region of human chromosome 11. Mol Carcinog. 13: 220-232, 1995.
White AE, Livanos EM, and Tlsty TD. Differential disruption of genomic integrity and cell cycle regulation in normal human fibroblasts by the HPV oncoproteins. Genes & Devel. 8: 666-667, 1994.
Witsell DL, Weissler MC, Livanos E, Bova-Hill C, and Gilmer, TM. Unique chromosomal rearrangement and mucin production in a novel salivary myoepithelial cell strain. Arch Otolaryngol Head Neck Surg. 119: 1151-1157, 1993.
Schaefer DI, Livanos EM, White AE, and Tlsty TD. Multiple mechanisms of N-(phosphonoacetyl)-L-aspartate drug resistance in SV40-infected precrisis human fibroblasts. Cancer Res. 53: 4946-4951, 1993.
Livingstone LR, White A, Sprouse J, Livanos E, Jacks T, and Tlsty TD. Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53. Cell. 70: 923-935, 1992.
Loh WE, Scrable HJ, Livanos E, Arboleda MJ, Cavenee WK, Oshimura M and Weissman BE. Human chromosome 11 contains two different growth suppressor genes for embryonal rhabdomyosarcoma. Proc Natl Acad Sci USA. 89: 1755-1759, 1992.
Dowdy SF, Fasching CL, Araujo D, Lai KM, Livanos E, Weissman BE and Stanbridge EJ. Suppression of tumorigenicity in Wilms tumor by the p15.5-p14 region of chromosome 11. Science 254: 293-295, 1991.
Publications resulting from KaryoLogic’s data
Sano S, Horitani K, Ogawa H, Halvardson J, Chavkin NW, Wang Y, Sano M, Mattisson J, Hata A, Danielsson M, Miura-Yura E, Zaghlool A, Evans MA, Fall T, De Hoyos HN, Sundstrom J, Yura Y, Kour A, Arai Y, Mychalekyj JC, Hirschi K, Forsberg LA, Walsh K. Hematopoietic loss of Y chromosome leads to cardiac fibrosis and heart failure mortality. Science 377: 292-297, 2022.
Firouzi F, Choudhury SS, Broughton K, Salazar A, Bailey B, and Sussman MA. Human CardioChimeras: Creation of a Novel “Next Generation” Cardiac Cell. JAHA (9) 1, 2020.
Molina SG, Beltran AA, Beltran AS. Generation of an integration-free induced pluripotent stem cell line (UNC001-A) from blood of a healthy individual. Stem Cell Research (49) 102015, 2020.
Liu Y, Patel GC, Mao W, Clark AF. Establishment of a conditionally immortalized mouse optic nerve astrocyte line. Experimental Eye Research 176: 188-195, 2018.
Teng PN, Bateman NW, Wang G, Litzi T, Blanton BE, Hood BL, Conrads KA, Ao W, Oliver KE, Darcy KM, McGuire WP, Paz K, Sidransky D, Hamilton CA, Maxwell GL, and Conrads TP. Establishment and characterization of platinum- and placlitaxel-resistant high grade serous ovarian carcinoma cell line. Human Cell 30, 226-236, 2017.
Zhao J, Davis MD, Martens YA, Shinohara M, Graff-Radford NR, Younkin SG, Wszolek, ZK, Kanekiyo T, and Bu G. APOE e4/e4 diminishes neurotrophic function of human iPSC-derived astrocytes. Hum Mol Genet 26(14) 2690-2700, 2017.
Taylor SM, Nevis KR, Park HL, Rogers GC, Rogers SL, Cook JG, and Bautch VL. Angiogenic factor signaling regulates centrosome duplication in endothelial cells of developing blood vessels. Blood 116 (16) 3108-3117, 2010.